Acronis 2018 Backup Error - "Read error or data content is corrupted"
Thank you for your posting! Do you have Parallels VMs or BootCamp included in the backup tasks? The above error often refers to issues with reading the BootCamp partition or virtual machines on the Mac (the file system inside VMs). I'd suggest trying to exclude BootCamp from backup and re-attempt the backup task.
Other possible reason are described in the KB Acronis True Image: Backup, recovery fail with error "Read error or data content is corrupted"